| Identification | Back Directory | [Name]
MX-69 | [CAS]
1005264-47-0 | [Synonyms]
MX-69
CS-2402
MX69 (MX 69
Benzoic acid, 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]- | [Molecular Formula]
C27H26N2O4S | [MOL File]
1005264-47-0.mol | [Molecular Weight]
474.57 |
| Hazard Information | Back Directory | [Uses]
MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment. | [in vivo]
MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo[1]. | [References]
[1] Lubing Gu, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636 DOI:10.1016/j.ccell.2016.08.015
[2] Gu L, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636 |
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