| Identification | Back Directory | [Name]
1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE | [CAS]
100991-92-2 | [Synonyms]
1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE
2-Hydroxymethyl-3,4-pyrrolidinediol hydrochloride
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride enzyme inhibitor
(2R,3R,4R)-3,4-Dihydroxy-2-(hydroxymethyl)pyrrolidine hydrochloride
3,4-Pyrrolidinediol, 2-(hydroxymethyl)-, hydrochloride, (2R,3R,4R)- | [Molecular Formula]
C5H12ClNO3 | [MDL Number]
MFCD03427380 | [MOL File]
100991-92-2.mol | [Molecular Weight]
169.61 |
| Chemical Properties | Back Directory | [Melting point ]
110-112 °C(Solv: ethyl ether (60-29-7); methanol (67-56-1)) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml | [form ]
A crystalline solid | [Water Solubility ]
water: 19.60-20.40mg/mL, clear, colorless to faintly yellow |
| Hazard Information | Back Directory | [Description]
1,4-dideoxy-1,4-imino-D-Arabinitol (DAB) is an inhibitor of glycogen phosphorylase, a key enzyme in glycogenolysis. It inhibits glycogenolysis in isolated liver cells (IC50 = 1.0 μM) and in homogenates of cerebral cortex and cerebellum (IC50s = 463 and 383 nM, respectively). DAB is used to inhibit glycogenolysis, in liver and in brain, in various animal models. | [Uses]
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride has been used as an α-glucosidase (GAA) inhibitor. | [General Description]
1,4-Dideoxy-1,4-imino-D-arabinitol is a naturally occurring pyrrolidine alkaloid. It is found in Arachniodes standishii and Angylocalyx boutiqueanus. | [Biochem/physiol Actions]
Inhibitor of glycogen phosphorylase and α-glucosidases. |
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