| Identification | Back Directory | [Name]
PD 116152 | [CAS]
101708-64-9 | [Synonyms]
PD 116152
Antibiotic PD-116152
6-Formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid methyl ester
6-Formyl-4,7,9-trihydroxy-8-methylphenazine-1-carboxylic acid methyl ester
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-8-methyl-, methyl ester | [Molecular Formula]
C16H12N2O6 | [MOL File]
101708-64-9.mol | [Molecular Weight]
328.28 |
| Hazard Information | Back Directory | [Description]
PD 116152 is a new, highly substituted phenazine with antitumor activity was isolated from the culture broth of a Streptomyces sp. It is a novel phenazine antitumor antibiotic. The antibiotic is selectively active versus the bacterium Streptococcus pneumoniae (MIC less than 0.46 microgram/ml); the antitumor activity versus murine P388 leukemia is T/C 149. | [Uses]
PD 116152 is a phenazine Antibiotic with antimicrobial and antitumor activity. PD 116152 possesses cytotoxic activity against L1210 lymphocytic leukemia and human colon adenocarcinoma (HCT-8) cells with IC50 values of 5.2 x 10-7 M and 7.1 x 10-7 M, respectively. PD 116152 is promising for research of P388 lymphocytic leukemia[1][2]. | [References]
[1] Smitka TA, et al. PD 116,152, a new phenazine antitumor antibiotic. Structure and antitumor activity. J Antibiot (Tokyo). 1986 Jun;39(6):800-3. DOI:10.7164/antibiotics.39.800
[2] Tunac J B, et al. PD 116, 152, a novel phenazine antitumor antibiotic discovery, fermentation, culture characterization and biological activity[J]. The Journal of Antibiotics, 1986, 39(2): 192-197. |
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