| Identification | Back Directory | [Name]
7H-pyrrolo[2,3-d]pyriMidine-5-carbaldehyde | [CAS]
1060815-89-5 | [Synonyms]
7H-pyrrolo[2,3-d]pyriMidine-5-carbaldehyde
7H-Pyrrolo[2,3-d]pyrimidine-5-carboxaldehyde
7H-Pyrrolo[2,3-d]pyrimidine-5-carbaldehyde 98% | [Molecular Formula]
C7H5N3O | [MDL Number]
MFCD13189361 | [MOL File]
1060815-89-5.mol | [Molecular Weight]
147.13 |
| Chemical Properties | Back Directory | [density ]
1.471±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
10.58±0.50(Predicted) | [Appearance]
Off-white to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
Under nitrogen protection, 7H-pyrrolo[2,3-d]pyrimidine (6 g, 50.4 mmol) and hexamethylenetetetramine (10.59 g, 76 mmol) were dissolved in a mixed solvent of acetic acid (20.00 mL) and water (40 mL). The reaction mixture was heated to reflux temperature with continuous stirring for 8 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solid product was collected by filtration. The solid was washed three times with ether to remove impurities. After drying, 5.6 g of 7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde was obtained in 76% yield. The product was analyzed by ESI-MS (+) showing m/z 148.1 [M+H]+. 1H NMR (methanol-d4) data were as follows: δ 10.00 (s, 1H), 9.43 (s, 1H), 8.91 (s, 1H), 8.40 (s, 1H). | [References]
[1] Patent: WO2017/176608, 2017, A1. Location in patent: Page/Page column 130; 131
[2] Patent: WO2012/2568, 2012, A1. Location in patent: Page/Page column 37 |
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Cool Pharm, Ltd
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021-58581007 18019463053 |
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www.coolpharm.com.cn |
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