| Identification | Back Directory | [Name]
Boc-D-Val-OMe | [CAS]
106391-85-9 | [Synonyms]
Boc-D-Val-OMe
BOC-D-VALINE METHYL ESTER
D-Boc valine methyl ester
N-BOC-D-VALINE METHYL ESTER
N-tert-Butoxycarbonyl-D-valine methyl ester
D-Valine,N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
methyl (2R)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanoate
methyl (2R)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate | [Molecular Formula]
C11H21NO4 | [MDL Number]
MFCD00672511 | [MOL File]
106391-85-9.mol | [Molecular Weight]
231.29 |
| Hazard Information | Back Directory | [Uses]
D-Boc Valine methyl ester is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1]. | [References]
[1] Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45. PMID:12702571 |
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Shanghai GL Peptide Ltd.
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Binhai gill polypeptide co. LTD
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