| Identification | Back Directory | [Name]
5-METHOXY-3-(1,2,5,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE HEMISUCCINATE | [CAS]
107008-28-6 | [Synonyms]
RU-24969
RU 24969 HEMISUCCINATE
5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole hemisuccinate
5-METHOXY-3-(1,2,5,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE HEMISUCCINATE
5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole succinate(2:1)
5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole succinate (2:1) salt
Butanedioic acid, compd. with 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (1:1) | [Molecular Formula]
C18H22N2O5 | [MDL Number]
MFCD00673955 | [MOL File]
107008-28-6.mol | [Molecular Weight]
346.38 |
| Hazard Information | Back Directory | [Uses]
RU 24969 Succinate is a SR-1A and SR-1B, and moderate SR-2C agonist. 5-HT1B/1A agonist. Also, it is a well-established substrate for human serotonin transporter (SERT). | [Biological Activity]
Potent 5-HT 1A/1B and moderate 5-HT 2C agonist that may also release 5-HT. Centrally active following systemic administration. | [in vivo]
RU 24969 succinate (1 and 3 mg/kg; s.c., once) potentiates addictive agent-induced effects[2].
RU 24969 succinate (0.03-3.0 mg/kg; s.c., once) dose-dependently decreases water consumption in water deprived rats[4]. | Animal Model: | Male Wistar rats with cocaine injection[2] | | Dosage: | 1 and 3 mg/kg | | Administration: | Subcutaneous injection; 1 and 3 mg/kg, once | | Result: | Increased cocaine-induced elevation of nucleus accumbens (NAcc) dopamine DA levels and reduction of ventral tegmental area (VTA) GABA levels.
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