| Identification | Back Directory | [Name]
Cochliodone A | [CAS]
1072931-48-6 | [Synonyms]
Cochliodone A
5,5''-Bispiro[3H-2-benzopyran-3,2'-[2H]pyran]-6,6'',8,8''(4H,4''H,7H,7''H)-tetrone, 7,7''-bis(acetyloxy)-3',3''',4',4''',5',5''',6',6'''-octahydro-6',6''',7,7''-tetramethyl-, (2'S,2'''S,5R,6'R,6'''R,7R,7''S)- | [Molecular Formula]
C34H38O12 | [MOL File]
1072931-48-6.mol | [Molecular Weight]
638.67 |
| Hazard Information | Back Directory | [Uses]
Cochliodone A is an active compound extracted from cultures of the deep-sea derived fungus Chaetomium sp. and has antibacterial and anticancer activity. Cochliodone A is toxic to a variety of bacteria, with MICs of 15.3 μg/mL (V. vulnificus), 32.7 μg/mL (V. rotiferianus), 15.9 μg/mL (S. aureus ATCC 43300), and 16.3 μg/mL (S . aureus CGMCC 1.12409). Cochliodone A also inhibits a variety of cancer cell lines, with IC50s of 28.1 μM (A549), 20.7 μM (HeLa), and 23.2 μM (Hep G2)[1]. | [References]
[1] Wang W, et al. Chlorinated Azaphilone Pigments with Antimicrobial and Cytotoxic Activities Isolated from the Deep Sea Derived Fungus Chaetomium sp. NA-S01-R1. Mar Drugs. 2018 Feb 13;16(2):61.. DOI:10.3390/md16020061 |
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