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ChemicalBook--->CAS DataBase List--->1093082-54-2

1093082-54-2

1093082-54-2 Structure

1093082-54-2 Structure
IdentificationBack Directory
[Name]

Carbamic acid, N-[3-[3-[[cyclopropyl[(2R)-2-morpholinylcarbonyl]amino]methyl]-1H-indol-1-yl]propyl]-, methyl ester
[CAS]

1093082-54-2
[Synonyms]

Renin inhibitor-1
Carbamic acid, N-[3-[3-[[cyclopropyl[(2R)-2-morpholinylcarbonyl]amino]methyl]-1H-indol-1-yl]propyl]-, methyl ester
[Molecular Formula]

C22H30N4O4
[MOL File]

1093082-54-2.mol
[Molecular Weight]

414.5
Chemical PropertiesBack Directory
[Boiling point ]

666.7±55.0 °C(Predicted)
[density ]

1.33±0.1 g/cm3(Predicted)
[pka]

12.56±0.46(Predicted)
Hazard InformationBack Directory
[Uses]

Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases[1].
[in vivo]

Renin inhibitor-1 (compound 26) (10 mg/kg; p.o.) demonstrates a significantly potent hypotensive effect in tsukuba hypertensive mice[1].

[References]

[1] Daisuke Iijima, et al. Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors. ACS Med. Chem. Lett. 2022, 13, 8, 1351–1357.
1093082-54-2 suppliers list
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Company Name: TargetMol Chemicals Inc.  
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