| Identification | Back Directory | [Name]
Carbamic acid, N-[3-[3-[[cyclopropyl[(2R)-2-morpholinylcarbonyl]amino]methyl]-1H-indol-1-yl]propyl]-, methyl ester | [CAS]
1093082-54-2 | [Synonyms]
Renin inhibitor-1
Carbamic acid, N-[3-[3-[[cyclopropyl[(2R)-2-morpholinylcarbonyl]amino]methyl]-1H-indol-1-yl]propyl]-, methyl ester | [Molecular Formula]
C22H30N4O4 | [MOL File]
1093082-54-2.mol | [Molecular Weight]
414.5 |
| Hazard Information | Back Directory | [Uses]
Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases[1]. | [in vivo]
Renin inhibitor-1 (compound 26) (10 mg/kg; p.o.) demonstrates a significantly potent hypotensive effect in tsukuba hypertensive mice[1]. | [References]
[1] Daisuke Iijima, et al. Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors. ACS Med. Chem. Lett. 2022, 13, 8, 1351–1357. |
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