| Identification | Back Directory | [Name]
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)- | [CAS]
109351-33-9 | [Synonyms]
(S)-Terazosin
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)-
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2S)-tetrahydro-2-furanyl]carbonyl]- (9CI) | [Molecular Formula]
C19H25N5O4 | [MOL File]
109351-33-9.mol | [Molecular Weight]
387.43 |
| Chemical Properties | Back Directory | [Boiling point ]
664.5±65.0 °C(Predicted) | [density ]
1.332±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 150 mg/mL (387.17 mM) | [form ]
Solid | [pka]
6.52±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity α-adrenoceptor antagonist with Ki values of 3.91 nM, 0.79 nM and 1.16 nM for α1a, α1b and α1d-adrenoceptor, respectively. (S)-Terazosin also has high-affinity for α2a, α2B and α2c-adrenoceptor with Ki values of 729 nM, 3.5 nM and 46.4 nM, respectively[1]. | [in vivo]
(S)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC30 of 6.93. (s)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 8.3 and 6.12, respectively[1]. | [IC 50]
α adrenergic receptor | [storage]
Store at -20°C | [References]
[1] Hancock AA, et al. Actions of terazosin and its enantiomers at subtypes of alpha 1- and alpha 2-adrenoceptors in vitro. J Recept Signal Transduct Res. 1995 Sep-Dec;15(7-8):863-85. DOI:10.3109/10799899509049862 |
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