| Chemical Properties | Back Directory | [Boiling point ]
992.3±65.0 °C(Predicted) | [density ]
1.281±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 10 mM | [form ]
A solid | [pka]
13.41±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Ac-WLA-AMC is a fluorogenic substrate for the β5c subunit of the 20S proteasome. Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify the activity of the β5c subunit of the 20S proteasome. AMC displays excitation/emission maxima of 351/430 nm, respectively. | [Uses]
Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate[1]. | [References]
[1] Kim S, et al. Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates. Immune Netw. 2022 Apr 15;22(3):e28. DOI:10.4110/in.2022.22.e28 |
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