天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->116308-38-4

116308-38-4

116308-38-4 Structure

116308-38-4 Structure
IdentificationBack Directory
[Name]

4-Pyridinecarbonitrile,2-formyl-(9CI)
[CAS]

116308-38-4
[Synonyms]

2-forMylisonicotinonitrile
2-Formylpyridine-4-carbonitrile
2-forMyl-4-pyridinecarbonitrile
4-Cyanopyridine-2-carboxaldehyde
4-Cyano-2-pyridinecarboxaldehyde
4-Pyridinecarbonitrile, 2-formyl-
4-Pyridinecarbonitrile,2-formyl-(9CI)
4-Pyridinecarbonitrile,2-formyl-(9CI) ISO 9001:2015 REACH
[Molecular Formula]

C7H4N2O
[MDL Number]

MFCD12546404
[MOL File]

116308-38-4.mol
[Molecular Weight]

132.12
Chemical PropertiesBack Directory
[Boiling point ]

201.0±20.0℃ (760 Torr)
[density ]

1.24±0.1 g/cm3 (20 ºC 760 Torr)
[Fp ]

75.4±21.8℃
[storage temp. ]

under inert gas (nitrogen or Argon) at 2-8°C
[pka]

-0.45±0.10(Predicted)
[Appearance]

Light yellow to yellow Solid
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22-43
[Safety Statements ]

36/37
Spectrum DetailBack Directory
[Spectrum Detail]

4-Pyridinecarbonitrile,2-formyl-(9CI)(116308-38-4)1HNMR
4-Pyridinecarbonitrile,2-formyl-(9CI)(116308-38-4)1HNMR
Hazard InformationBack Directory
[Synthesis]

4-CYANO-PYRIDINE-2-METHANOL

51454-63-8

4-Pyridinecarbonitrile,2-formyl-(9CI)

116308-38-4

Oxalyl chloride (13.2 mL, 150 mmol) was dissolved in anhydrous dichloromethane (86 mL) under nitrogen protection and cooled to -78°C. Dimethyl sulfoxide (21.2 mL) was added slowly dropwise over 20 min and the reaction mixture was stirred at -78°C for 15 min. Subsequently, 4-cyanopyridine-2-methanol (4.0 g, 30 mmol) dissolved in anhydrous dichloromethane (60 mL) was added dropwise to the reaction mixture over a period of 5 min and stirring was continued for 2 h while maintaining -78°C and a nitrogen atmosphere. Formation of a white solid precipitate was observed during the reaction. The reaction temperature was raised to -55°C and triethylamine (6.15 mL, 450 mmol) was added dropwise over 15 minutes. The cooling bath was removed and the reaction mixture was allowed to warm naturally to room temperature over a period of 2 hours. Upon completion of the reaction, the mixture was diluted with dichloromethane (400 mL), washed successively with brine (2 x 50 mL), and the aqueous phase was then back-extracted with dichloromethane (3 x 50 mL). All organic layers were combined and concentrated under reduced pressure to give a light yellow solid product. The product did not require further purification and showed a single peak by LC-MS analysis with a retention time (RT) of 2.53 min and a mass spectrometry (M + H) peak located at m/z 133.0 in quantitative yield.

[References]

[1] Patent: WO2006/21801, 2006, A1. Location in patent: Page/Page column 65-66
[2] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[3] Patent: US6043248, 2000, A
[4] Patent: WO2006/21801, 2006, A1. Location in patent: Page/Page column 46-47
[5] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 559 - 576
116308-38-4 suppliers list
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Website: www.hubeijusheng.com
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Website: www.approvedhomemanagement.com/ShowSupplierProductsList454175/0_EN.htm
Company Name: Nanjing jinheyou Trading Co., Ltd.
Tel: 15705188088
Website: http://www.approvedhomemanagement.com/manufacturer/nanjing-jinheyou-trading-190/
Company Name: Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel: +8613580539051 , +8613580539051
Website: www.yuhengpharm.com
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: ANHUI WITOP BIOTECH CO., LTD
Tel: +8615255079626 , +8615255079626
Website: www.approvedhomemanagement.com/ShowSupplierProductsList418627/0_EN.htm
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-89586680 +86-18192503167 , +86-18192503167
Website: www.dideu.com
Company Name: Hefei Hirisun Pharmatech Co., Ltd
Tel: +8615056975894 , +8615056975894
Website: www.hirisunpharm.com
Company Name: Hunan Jibang Biological Technology Co., LTD
Tel: +8613776644403 , +8613776644403
Website: www.approvedhomemanagement.com/ShowSupplierProductsList124423/0_EN.htm
Company Name: SUZHOU SENFEIDA CHEMICAL CO.,LTD
Tel: +86-0512-83500002 +8618662433356 , +8618662433356
Website: www.sfdchem.com/
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: Suzhou ARTK Medchem Co., Ltd.
Tel: +86-512-68323658 +86-18168183658 , +86-18168183658
Website:
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Shanghai Hanhong Scientific Co.,Ltd.  
Tel: 021-54306202 13764082696
Website: https://www.hanhongsci.com
Company Name: Jinan Trio PharmaTech Co., Ltd.  
Tel: 0531-88811783
Website: www.trio-pharmatech.com
Company Name: Shanghai Synthfine Chemical Co.,Ltd  
Tel: 15921303235
Website: http://www.synthfine.com
Company Name: Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.  
Tel: 025-66113011 17798518460
Website: www.aikonchem.com/
Tags:116308-38-4 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.