| Identification | Back Directory | [Name]
ES 6864 | [CAS]
116326-39-7 | [Synonyms]
ES 6864
(3S,4S)-3-Hydroxy-5-cyclohexyl-4-[[(2S)-3-(4-thiazolyl)-2-[[(2R)-2-(morpholinocarbonylmethyl)-3-(1-naphthalenyl)propionyl]amino]propionyl]amino]-N-(2-morpholinoethyl)valeramide
(3S,4S)-3-Hydroxy-5-cyclohexyl-4-[[(2S)-3-(4-thiazolyl)-2-[[(2R)-2-[morpholinocarbonylmethyl]-3-(1-naphthalenyl)propionyl]amino]propionyl]amino]-N-(2-morpholinoethyl)valeramide
5-Cyclohexyl-2,4,5-trideoxy-N-[2-(4-morpholinyl)ethyl]-4-[[(2S)-2-[[(2R)-4-(4-morpholinyl)-2-(1-naphthalenylmethyl)-1,4-dioxobutyl]amino]-1-oxo-3-(4-thiazolyl)propyl]amino]-L-threo-pentonamide
L-threo-Pentonamide, 5-cyclohexyl-2,4,5-trideoxy-N-[2-(4-morpholinyl)ethyl]-4-[[(2S)-2-[[(2R)-4-(4-morpholinyl)-2-(1-naphthalenylmethyl)-1,4-dioxobutyl]amino]-1-oxo-3-(4-thiazolyl)propyl]amino]- (9CI)
(3S,4S)-5-cyclohexyl-3-hydroxy-4-3-(4-thiazolyl)-L-alanyl>aMino-N-(2-Morpholinoethyl)pentanaMide|(3S,4S)-5-cyclohexyl-3-hydroxy-4{N-[2(R)-(1-naphthyl)Methyl-3-Morpholinocarbonylpropi
onyl]-3-(4-th | [Molecular Formula]
C42H58N6O7S | [MDL Number]
MFCD00877176 | [MOL File]
116326-39-7.mol | [Molecular Weight]
791.01 |
| Hazard Information | Back Directory | [Description]
ES 6864 is an orally active renin inhibitor. | [Uses]
ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets[1]. | [References]
[1] Hiwada K, et al., A highly potent and long-acting oral inhibitor of human renin. Hypertension. 1988 Jun;11(6 Pt 2):708-12. DOI:10.1161/01.hyp.11.6.708 |
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| Company Name: |
Alabiotech Inc.
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| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
| Company Name: |
CHEMICAL LAND21
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| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
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