| Identification | Back Directory | [Name]
Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI) | [CAS]
120241-79-4 | [Synonyms]
3-TYP
CS-2754
Pyridine(3-TYP)
3-TYP;3 TYP;3TYP
3-triazol-4-yl) pyridine
3-(1H-1,2,3-triazol-4-yl)pyridine
Pyridine,3-(1H-1,2,3-triazol-5-yl)-
Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI)
3-(1H-1;2;3-TRIAZOL-4-YL) PYRIDINE;3 TYP;3TYP | [Molecular Formula]
C7H6N4 | [MDL Number]
MFCD25956467 | [MOL File]
120241-79-4.mol | [Molecular Weight]
146.15 |
| Chemical Properties | Back Directory | [Melting point ]
180-182 °C(Solv: ethyl acetate (141-78-6); ethyl ether (60-29-7)) | [Boiling point ]
386.6±17.0 °C(Predicted) | [density ]
1.296±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid | [pka]
7.54±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
3-(1H-1,2,3-Triazol-4-yl)pyridine is a reactant used in the synthesis of 4-aryl-1H-1,2,3-triazoles which possesses more Indoleamine 2,3-dioxygenase (IDO) inhibitory potency than the most commonly used 1-methyltryptophan. | [in vivo]
3-TYP (50 mg/kg, i.p.) does not significantly influence the LVEF, LVFS, infarct size, serum LDH levels, apoptosis, and oxidative stress compared with those of the Sham group. Moreover, 3-TYP has little effect on gp91phox, Nrf2, NQO 1, Bax, Bcl-2, Caspase-3, and cleaved Caspase-3 expression levels, compared with the Sham group. 3-TYP significantly decreases SIRT3 activity and increases the acetylation of SOD2 compared with that in the control group, without influencing SIRT3 expression. 3-TYP attenuates the cardioprotective effects of melatonin by decreasing the LVEF and LVFS after 24 hour of reperfusion. 3-TYP also increases the infarct size, serum LDH levels, and apoptotic ratio compared with those in the IR+Mel group[2]. | [IC 50]
SIRT3: 38 μM (IC50); Methionine Aminopeptidase 2 | [storage]
Store at -20°C |
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