| Identification | Back Directory | [Name]
salvinolone | [CAS]
120278-22-0 | [Synonyms]
salvinolone
(S)-2,3,4,4a-Tetrahydro-5,6-dihydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone
9(1H)-Phenanthrenone, 2,3,4,4a-tetrahydro-5,6-dihydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-, (4aS)- | [Molecular Formula]
C20H26O3 | [MOL File]
120278-22-0.mol | [Molecular Weight]
314.42 |
| Hazard Information | Back Directory | [Description]
Salvinolone, demethyl cryptojaponol and taxodione show potent activity with 4-10 microg/mL of MIC against MRSA and 4-16 microg/mL of MIC against VRE. | [Uses]
Salvinolone is active against methicillin-resistant?Staphylococcus aureus?(MRSA) and vancomycin-resistant?Enterococcus?(VRE). Salvinolone shows cytotoxic activity with an IC50 of 47.6 μM against the HL-60 tumor cell line for 72 h[1][2]. | [target]
Antifection | [References]
[1] Mingfeng Xu, et al. Bioactive diterpenes from Clerodendrum kaichianum. Nat Prod Commun. 2011 Jan;6(1):3-5. PMID:21366034
[2] EnriqueAlvarez-Manzaneda, et al. First synthesis of picealactone C. A new route toward taxodione-related terpenoids from abietic acid. Tetrahedron Letters, Volume 48, Issue 6, 5 February 2007, Pages 989-992. |
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