| Identification | Back Directory | [Name]
LCB 03-0110
(LCB03-0110) | [CAS]
1228102-01-9 | [Synonyms]
LCB 03-0110
LCB 03-0110
(LCB03-0110)
Phenol, 3-[[2-[3-(4-morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]- | [Molecular Formula]
C24H23N3O2S | [MOL File]
1228102-01-9.mol | [Molecular Weight]
417.52 |
| Hazard Information | Back Directory | [Uses]
LCB 03-0110, a thienopyridine derivative, is a potent pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor. LCB 03-0110 suppresses scar formation by inhibiting fibroblast and macrophage activation[1]. | [in vivo]
LCB 03-0110 suppresses the accumulation of myofibroblast and macrophage cells in the healing wound and reduced hypertrophic scar formation after wound closing on rabbit ears[1]. | [References]
[1] Sun X, et, al. LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J Pharmacol Exp Ther. 2012 Mar;340(3):510-9. DOI:10.1124/jpet.111.187328 |
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