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ChemicalBook--->CAS DataBase List--->1252802-38-2

1252802-38-2

1252802-38-2 Structure

1252802-38-2 Structure
IdentificationBack Directory
[Name]

NMK-TD 100
[CAS]

1252802-38-2
[Synonyms]

NMK-TD100
NMK-TD-100
NMK-TD 100
[Molecular Formula]

C19H17N3O3S
[MOL File]

1252802-38-2.mol
[Molecular Weight]

367.42
Hazard InformationBack Directory
[Description]

NMK-TD-100 is a novel microtubule modulating agent. NMK-TD-100 blocks mitosis and induces apoptosis in HeLa cells by binding to tubulin. Polymerization of tissue purified tubulin into microtubules was inhibited by NMK-TD-100 with an IC50 value of 17.5±0.35 μM. The binding of NMK-TD-100 to tubulin was estimated to be ~10 times faster than that of colchicine. NMK-TD-100 exerted anti-proliferative activity by disrupting microtubule functions through tubulin binding and provided insights into its potential of being a chemotherapeutic agent.
[Uses]

NMK-TD-100 is a modulator for microtubule. NMK-TD-100 binds to tubulin, inhibits the tubulin polymerization with an IC50 of 17.5 μM, inhibits mitosis, and decreases mitochondrial membrane potential (MMP). NMK-TD-100 inhibits the proliferation of HeLa with an IC50 of 1.42 μM, arrests cell cycle at G2/M phase, induces apoptosis in HeLa[1].
[References]

[1] Bhattacharya S, et al., NMK-TD-100, a novel microtubule modulating agent, blocks mitosis and induces apoptosis in HeLa cells by binding to tubulin. PLoS One. 2013 Oct 7;8(10):e76286. DOI:10.1371/journal.pone.0076286
1252802-38-2 suppliers list
Company Name: TargetMol Chemicals Inc.
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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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