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Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp. (ATCC 53693), a producer of several novel tetracycline derivatives. The major fermentation products, dactylocyclines A and B, were purified and MIC values determined against tetracycline-resistant and tetracycline-sensitive Gram-positive bacteria. The dactylocyclines represent the first naturally occurring tetracycline C2 amides which lack cross resistance with tetracycline. | [Uses]
Dactylocycline B, an antibiotic, is active against gram-positive bacteria, including tetracycline-resistant bacteria[1]. | [References]
[1] Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. II. Structure elucidation. J Antibiot (Tokyo). 1992 Dec;45(12):1899-906. DOI:10.7164/antibiotics.45.1899
[2] Carol A., et al. Dactylocycline A and dactylocycline B. Patent US5024839A. |
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