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ChemicalBook--->CAS DataBase List--->1260530-25-3

1260530-25-3

1260530-25-3 Structure

1260530-25-3 Structure
IdentificationBack Directory
[Name]

GSK-525768A
[CAS]

1260530-25-3
[Synonyms]

GSK525768A
GSK-525768
GSK-525768A
GSK 525768A
GSK525768A; GSK-525768A
(4R)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide
4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-4-acetamide, 6-(4-chlorophenyl)-N-ethyl-8-methoxy-1-methyl-, (4R)-
[Molecular Formula]

C22H22ClN5O2
[MDL Number]

MFCD25372039
[MOL File]

1260530-25-3.mol
[Molecular Weight]

423.9
Chemical PropertiesBack Directory
[Melting point ]

140-145℃
[density ]

1.35±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[pka]

15.71±0.46(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

GSK 525768A is the inactive enantiomer of GSK525762A. GSK 525768A has no activity towards BET.
[storage]

Store at -20°C
[References]

[1] Nicodeme E, et al. Suppression of inflammation by a synthetic histone mimic. Nature. 2010 Dec 23;468(7327):1119-23. DOI:10.1038/nature09589
[2] Filippakopoulos P, et al. Targeting bromodomains: epigenetic readers of lysine acetylation. Nat Rev Drug Discov. 2014 May;13(5):337-56. DOI:10.1038/nrd4286
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