| Identification | Back Directory | [Name]
N-Desethylsunitinib hydrochloride | [CAS]
1261432-05-6 | [Synonyms]
N-Desethyl sunitinib HCl
N-Desethylsunitinib hydrochloride
N Desethylsunitinib hydrochloride,NDesethylsunitinib hydrochloride | [Molecular Formula]
C20H24ClFN4O2 | [MOL File]
1261432-05-6.mol | [Molecular Weight]
406.89 |
| Hazard Information | Back Directory | [Uses]
(E/Z)-N-Desethylsunitinib hydrochloride ((E/Z)-SU-12662 hydrochloride) is a compound with potential anti-tumor activity that inhibits VEGF-R2 and PDGF-Rβ tyrosine kinases. (E/Z)-N-Desethylsunitinib hydrochloride is the main active metabolite of sunitinib and has the ability to competitively inhibit ATP[1]. | [References]
[1] Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase DOI:10.1021/jm0204183 |
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