| Identification | Back Directory | [Name]
H-CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH | [CAS]
126738-34-9 | [Synonyms]
SRTX-A, S6A
SARAFOTOXIN A
SARAFOTOXIN S6A
SARAFOTOXIN S6A1
M.W. 2514.85 C105H156N28O34S5
SARAFOTOXIN A (ATRACTASPIS ENGADDENSIS)
SARAFOTOXIN S6A (ATRACTASPIS ENGADDENSIS)
CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP
H-CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH
CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP (DISULFIDE BRIDGE: CYS1- CYS15, CYS3-CYS11)
Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp(Disulfide bridge: Cys1 and Cys15/Cys3 and Cys11)
L-Tryptophan, L-cysteinyl-L-seryl-L-cysteinyl-L-lysyl-L-α-aspartyl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-leucyl-L-asparaginyl-L-phenylalanyl-L-cysteinyl-L-histidyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide) | [Molecular Formula]
C105H156N28O34S5 | [MDL Number]
MFCD00133808 | [MOL File]
126738-34-9.mol | [Molecular Weight]
2514.85 |
| Chemical Properties | Back Directory | [Boiling point ]
2591.7±65.0 °C(Predicted) | [density ]
1.298±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridge:Cys1-Cys15;Cys3-Cys11) |
| Hazard Information | Back Directory | [Uses]
Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist?and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC50?value of 7.5 nM[1]. | [IC 50]
ETB; ETA | [References]
[1] P Schoeffter, et al. Differences between endothelin receptors mediating contraction of guinea-pig aorta and pig coronary artery. Eur J Pharmacol DOI:10.1016/0014-2999(93)90433-i |
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