| Identification | Back Directory | [Name]
CARBAZOCHROME SODIUM SULFONATE TRIHYDRATE | [CAS]
13051-01-9 | [Synonyms]
statimo
adrenosem
andenogen
adrestat-f
adrenosemsalicylate
CARBAZOCHROME SODIUM
ne5-semicarbazone(1:1)
salicylicacid,adrenosem
CARBAZOCHROME SALICYLATE
adrenochrome semicarbazone salicylate
CARBAZOCHROME SODIUM SULFONATE TRIHYDRATE
adrenochromemonosemicarbazonesodiumsalicylatecomplex
andrenochromemonosemicarbazonesodiumsalicylatecomplex
salicylicacid,monosodiumsalt,compd.with3-hydroxy-1-methyl-5,6-indolinedio
1-METHYL-6-OXO-2,3,5,6-TETRAHYDROINDOLE-5-SEMICARBAZONO-2-SULFONIC ACID SODIUM SALT 3 HYDRATE
Benzoic acid, 2-hydroxy-, sodium salt compd. with 2-(1,2,3,6-tetrahydro-3-hydroxy-1-methyl-6-oxo-5H-indol-5-ylidene)hydrazinecarboxamide (1:1:1) | [EINECS(EC#)]
235-927-1 | [Molecular Formula]
C10H17N4NaO8S | [MDL Number]
MFCD01684387 | [MOL File]
13051-01-9.mol | [Molecular Weight]
376.32 |
| Hazard Information | Back Directory | [Originator]
Adrenosem,Beecham,US,1953 | [Uses]
Carbazochrome salicylate is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome salicylate is an antihemorrhagic agent[1]. | [Manufacturing Process]
A suspension containing 1 part by weight of adrenalin and 2 to 6 parts by
weight of silver oxide in 150 to 250 parts by weight of methanol or ethanol is
stirred for about 10 minutes. The alcoholic adrenochrome solution obtained is
separated by draining and the filtrate is quickly evaporated to dryness at low
temperature and in vacuo. The red crystals of adrenochrome obtained are
dissolved in 45 to 55 parts by weight of water. To this solution, 2 parts of
sodium acetate dissolved in 2 to 3 parts of water and 2 parts of semicarbazide
hydrochloride dissolved in 2 to 3 parts of water are added. The formed
precipitate consisting of red-orange prismatic needles is separated by filtration
and recrystallized from diluted ethanol. There is obtained 0.30 to 0.40 part by
weight of adrenochrome monosemicarbazone dihydrate, melting at 203°C with
decomposition. | [Therapeutic Function]
Hemostatic | [References]
[1] Toshiaki Sendo, et al. Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):175-80. DOI:10.1007/s00210-003-0785-5
[2] Toshiaki Sendo, et al. Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Eur J Pharmacol. 2002 Aug 23;450(2):203-8. DOI:10.1016/s0014-2999(02)02120-9 |
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