| Identification | Back Directory | [Name]
NISTOSE | [CAS]
13133-07-8 | [Synonyms]
NISTOSE
NYSTOSE
1)-α-D-Glup
Nystose ,98%
fungitetraose
β-D-Fruf-(2->
1,1-Kestotetraose
NISTOSE USP/EP/BP
1)-β-D-Fruf-(2<
1)-β-D-Fruf-(2->
NistoseTrihydrate>
Fungitetraose
Nystose
1)-b-D-fructofuranosyl
1,1-Kestotetraose - 100mg
Fructo-oligosaccharide DP4/GF3
1)-O-b-D-fructofuranosyl-(2®
a-D-Glucopyranoside, O-b-D-fructofuranosyl-(2®
β-d-fruf-(2->1)-β-d-fruf-(2->1)-β-d-fruf-(2<->1)-α-d-glup
Nystose,β-D-Fruf-(2->1)-β-D-Fruf-(2->1)-β-D-Fruf-(2<-->1)-α-D-Glup
1-O-(1-O-β-D-Fructofuranosyl-β-D-fructofuranosyl)-β-D-fructofuranosyl α-D-glucopyranoside
a-D-Glucopyranoside, O-b-D-fructofuranosyl-(21)-O-b-D-fructofuranosyl-(21)-b-D-fructofuranosyl
α-D-Glucopyranoside, O-β-D-fructofuranosyl-(2→1)-O-β-D-fructofuranosyl-(2→1)-β-D-fructofuranosyl
2-O-(2-O-α-D-Glucopyranosyl-1-deoxy-β-D-fructofuranose-1-yl)-1-deoxy-β-D-fructofuranose-1-yl β-D-fructofuranoside
(2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
(2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-3,4-dihydroxy-2,5-dimethylol-tetrahydrofuran-2-yl]oxymethyl]-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]oxymethyl]-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]oxy-6-methylol-tetrahydropyran-3,4,5-triol
(2R,3R,4S,5S,6R)-2-(((2S,3S,4S,5R)-2-((((2R,3S,4S,5R)-2-((((2R,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | [Molecular Formula]
C24H42O21 | [MDL Number]
MFCD00191672 | [MOL File]
13133-07-8.mol | [Molecular Weight]
666.58 |
| Chemical Properties | Back Directory | [Melting point ]
130-133℃ | [Boiling point ]
1075.7±65.0 °C(Predicted) | [density ]
1.84±0.1 g/cm3 (20 ºC 760 Torr) | [refractive index ]
10 ° (C=4, H2O) | [storage temp. ]
2-8°C
| [solubility ]
H2O : 300 mg/mL (450.06 mM; Need ultrasonic and warming) | [form ]
neat | [pka]
12.76±0.70(Predicted) | [color ]
White to off-white | [BRN ]
6171779 | [InChIKey]
FLDFNEBHEXLZRX-DLQNOBSRSA-N |
| Hazard Information | Back Directory | [Chemical Properties]
White crystal | [Uses]
Fungitetraose is a part of the sugar mixture of Neosugar, sweetner. | [Definition]
ChEBI: Nystose is an oligosaccharide. | [Synthesis]
The general procedure for the synthesis of the target compound from the compound (CAS: 25101-99-9) was as follows: 100 mg of Hex4perAc was dissolved in 5 mL of methanol (MeOH), followed by the addition of 18 mg (0.3 eq.) of sodium methanolate (CH3ONa). After stirring the reaction mixture for 2.5 h at room temperature, Dowex 50Wx2 [H+] resin was added to neutralize the reaction solution. The resin was removed by filtration and the solvent was removed by distillation under reduced pressure. The residue was dissolved in water (H2O) and desalted using a Bio-Gel P-2 gel (10 mL). Finally, a white solid product (57 mg) was obtained by freeze-drying. | [in vivo]
Nystose (100 mg/kg, po for 14 days) enhances the intestinal IgA secretion and modulates systemic immune responses in BALB/c mouse models[2].
Nystose (40-160 mg/kg, po for 8 weeks) improves the bone density and bone microstructure in mouse models[3].
| Animal Model: | BALB/c mouse models[2] | | Dosage: | 100 mg/kg | | Administration: | po for 14 days | | Result: | Inhibited the secretion of IL-2, IFN-γ, IL-12 and IL-4 by splenocytes. |
| Animal Model: | ICR mouse models[3] | | Dosage: | 40-160 mg/kg | | Administration: | po for 8 weeks | | Result: | Improved the bone density and bone microstructure. |
| [target]
IFN-γ | IL Receptor | [References]
[1] Patent: CN103638162, 2016, B. Location in patent: Paragraph 0056
[2] Molecules, 2018, vol. 23, # 2, |
|
|