Identification | Back Directory | [Name]
Benzenesulfonamide, 2-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N,N-dimethyl- | [CAS]
1341200-61-0 | [Synonyms]
HCI2184 HCI-2184 HCI 2184 Benzenesulfonamide, 2-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N,N-dimethyl- | [Molecular Formula]
C23H28ClN7O2S | [MOL File]
1341200-61-0.mol | [Molecular Weight]
502.03 |
Hazard Information | Back Directory | [Description]
HCI-2184 is a Nek2 inhibitor. It acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma/ It is also a potent AXL kinase inhibitor. | [Uses]
HCI-2184 is a Nek2 inhibitor with an IC50 of 39.90 nM. HCI-2184 significantly increases the effectiveness of Bortezomib (HY-10227) in inhibiting proteasome activity[1]. | [References]
[1] Meng L, et al. Inhibition of Nek2 by small molecules affects proteasome activity. Biomed Res Int. 2014;2014:273180. DOI:10.1155/2014/273180 |
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