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ChemicalBook--->CAS DataBase List--->1341200-61-0

1341200-61-0

1341200-61-0 Structure

1341200-61-0 Structure
IdentificationBack Directory
[Name]

Benzenesulfonamide, 2-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N,N-dimethyl-
[CAS]

1341200-61-0
[Synonyms]

HCI2184
HCI-2184
HCI 2184
Benzenesulfonamide, 2-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N,N-dimethyl-
[Molecular Formula]

C23H28ClN7O2S
[MOL File]

1341200-61-0.mol
[Molecular Weight]

502.03
Chemical PropertiesBack Directory
[Boiling point ]

676.9±65.0 °C(Predicted)
[density ]

1.361±0.06 g/cm3(Predicted)
[pka]

7.87±0.42(Predicted)
Hazard InformationBack Directory
[Description]

HCI-2184 is a Nek2 inhibitor. It acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma/ It is also a potent AXL kinase inhibitor.
[Uses]

HCI-2184 is a Nek2 inhibitor with an IC50 of 39.90 nM. HCI-2184 significantly increases the effectiveness of Bortezomib (HY-10227) in inhibiting proteasome activity[1].
[References]

[1] Meng L, et al. Inhibition of Nek2 by small molecules affects proteasome activity. Biomed Res Int. 2014;2014:273180. DOI:10.1155/2014/273180
1341200-61-0 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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