| Identification | Back Directory | [Name]
2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-, (3,5,6-trimethyl-2-pyrazinyl)methyl ester | [CAS]
1344715-94-1 | [Synonyms]
Antiproliferative agent-20
2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-, (3,5,6-trimethyl-2-pyrazinyl)methyl ester | [Molecular Formula]
C23H18N2O6 | [MOL File]
1344715-94-1.mol | [Molecular Weight]
418.4 |
| Hazard Information | Back Directory | [Uses]
Antiproliferative agent-20 is a potent and orally active anticancer agent. Antiproliferative agent-20 exhibits antiproliferative and anti-angiogenic activities[1]. | [in vivo]
Antiproliferative agent-20 (10-40 μg/egg) inhibits the angiogenesis of the chick chorioallantoic membrane (CAM)[1].
Antiproliferative agent-20 (3.2 g/kg; p.o.) shows no deaths or signs of toxicity in mice during two weeks[1].
Antiproliferative agent-20 (24 h) does not be hydrolyzed in 37℃ artificial gastric juice and artificial intestinal liquid[1]. | [References]
[1] WANG PL, et, al. Synthesis and Antitumor Evaluation of One Novel Tetramethylpyrazine-Rhein Derivative. Asian Journal of Chemistry (2013), 25(9), 4885-4888. |
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