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ChemicalBook--->CAS DataBase List--->1354825-62-9

1354825-62-9

1354825-62-9 Structure

1354825-62-9 Structure
IdentificationBack Directory
[Name]

WEHI-345 (analog)
[CAS]

1354825-62-9
[Synonyms]

WEHI-345 alog
WEHI-345 (analog)
WEHI-345 analogue
Reaxys ID: 22174618
2-Pyridinecarboxamide, N-[2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-3-methyl-
[Molecular Formula]

C23H25N7O
[MOL File]

1354825-62-9.mol
[Molecular Weight]

415.49
Chemical PropertiesBack Directory
[Boiling point ]

688.0±55.0 °C(Predicted)
[density ]

1.30±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : ≥ 30 mg/mL (72.20 mM)
[form ]

Solid
[pka]

12.67±0.46(Predicted)
[color ]

White to gray
Hazard InformationBack Directory
[Uses]

WEHI-345 analog is the analog of WEHI-345. WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation[1].
[IC 50]

RIPK2
[storage]

Store at -20°C
[References]

[1] Nachbur U, et al. A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production. Nat Commun. 2015 Mar 17;6:6442. DOI:10.1038/ncomms7442
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