| Identification | Back Directory | [Name]
LIN28 inhibitor LI71 | [CAS]
1357248-83-9 | [Synonyms]
LIN28 inhibitor LI71
Benzoic acid, 4-[(3aS,4R,9bR)-6-ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]- | [Molecular Formula]
C21H21NO3 | [MDL Number]
MFCD07363437 | [MOL File]
1357248-83-9.mol | [Molecular Weight]
335.4 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);298.15(Max Conc. mM) | [form ]
Solid | [color ]
Yellow to green |
| Hazard Information | Back Directory | [Uses]
LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM. LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28’s activity against let-7 in leukemia cells and embryonic stem cells[1]. | [storage]
Store at -20°C | [References]
[1] Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 Jun 5;23(10):3091-3101. DOI:10.1016/j.celrep.2018.04.116 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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