| Identification | Back Directory | [Name]
Ulocuplumab | [CAS]
1375830-34-4 | [Synonyms]
Ulocuplumab
Ulocuplumab (anti-CXCR4)
Research Grade Ulocuplumab(DHF39901) |
| Hazard Information | Back Directory | [Uses]
Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models[1][2]. | [in vivo]
Ulocuplumab (3-30 mg/kg; i.p.; every 3-4 days for 5 doses; 65 days in total) inhibits tumor growth of multiple myeloma xenograft models in mice, including Ramos B cells, HL-60 cells, MOLP-8 cells, Nomo-1 cells, and JJN-3R cells models[1].
| Animal Model: | Severe combined immunodeficient (SCID) mice of AML model (MOLP-8 cells)[1] | | Dosage: | 3-30 mg/kg | | Administration: | Intraperitoneal injection; every 3-4 days for 5 doses; last for 65 days | | Result: | Significantly delayed mean tumor growth by 66% and 56% when compared with isotype control on day 25. |
| [IC 50]
CXCR4 | [References]
[1] Kashyap MK, et al. Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway. Oncotarget. 2016 Jan 19;7(3):2809-22. DOI:10.18632/oncotarget.6465
[2] Kuhne MR, et al. BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies. Clin Cancer Res. 2013 Jan 15;19(2):357-66. DOI:10.1158/1078-0432.CCR-12-2333 |
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| Company Name: |
Biolab Reagents
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| Tel: |
18108604356 18108604356 |
| Website: |
www.biolabreagent.com/ |
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