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ChemicalBook--->CAS DataBase List--->139262-76-3

139262-76-3

139262-76-3 Structure

139262-76-3 Structure
IdentificationBack Directory
[Name]

4,4′-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-Butenoic acid
[CAS]

139262-76-3
[Synonyms]

H2L5186303
H2L5186303 >=98% (HPLC)
4,4′-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-Butenoic acid
(Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid
(2Z,2′Z)-4,4′-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid
2-Butenoic acid, 4,4'-[1,3-phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-, (Z,Z)- (9CI)
[Molecular Formula]

C26H20N2O8
[MOL File]

139262-76-3.mol
[Molecular Weight]

488.45
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble25mg/mL, clear
[form ]

powder
[color ]

white to beige
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

H2L5186303 (139262-76-3) is a potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist.? IC50?= 8.9 nM, 1230 nM and 27.35 μM for LPA2, LPA3, and LPA1 respectively.1,2
[Uses]

H2L5186303 is an antidepressant acting on the LPA1 (lysophosphatidic acid receptor 1) and induce insulin-like growth factor-I receptor transactivation as well as causing enhanced cell proliferation.
[Biochem/physiol Actions]

H2L5186303 is specific antagonist of the lysophosphatidic acid receptor LPA2 (Ki = 7.2 nM). The compound H2L5186303 displays 40- to 1800-fold selectivity over other LPA receptors.
[in vivo]

H2L5186303 (0-50 mg/kg, given by intraperitoneal injection, single dose) suppresses the levels of eosinophils and lymphocytes in OVA-sensitized mice, and has the trachea inflammation inhibitory effect[2].
H2L5186303 (10 mg/kg, given by intraperitoneal injection, three times every other day, 6 days) inhibits cell proliferation in Lpar5f/f Villin-Cre mice intestinal crypts and promotes apoptosis[3].

Animal Model:Ovalbumin-Induced allergic asthma in BALB/c mice[2]
Dosage:1 mg/kg, single dose; 0, 6.25, 12.5, 25, 50 mg/mL, single dose
Administration:Intraperitoneal injection (i.p.)
Result:Showed strong inhibitory effects, reducing airway hyper-responsiveness, levels of inflammatory cytokines, mucus production, and the number of eosinophils before sensitization and toxin exposure in OVA.
Lowered AHR and inflammation scores.
Suppressed mRNA levels of IL-4, IL-13, and IFN-γ, but did not inhibit IgE levels.
Animal Model:Lpar5f/f Villin-Cre mice[3]
Dosage:10 mg/kg, every other day for three times, 6 days
Administration:Intraperitoneal injection (i.p.)
Result:Reduced the number of proliferating cells in the intestinal crypts of mice and increased cell apoptosis.
[IC 50]

LPA2 Receptor: 9 nM (IC50)
[storage]

Store at -20°C
[References]

1) Fells?et al. (2008)?Identification of non-lipid LPA3 antagonists by virtual screening; Bioorg. Med. Chem.?16?6207 2) Fells?et al. (2009)?Structure-based drug design identifies novel LPA3 antagonists; Bioorg. Med. Chem. 17?7457
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