Identification | Back Directory | [Name]
Propanedioic acid, 2-[(1R)-3-oxo-1-phenyl-3-[4-(trifluoroMethyl)phenyl]propyl]- | [CAS]
1410101-89-1 | [Synonyms]
(R)-PS210 MLJPLHGJBUWCBA-AWEZNQCLSA-N Propanedioic acid, 2-[(1R)-3-oxo-1-phenyl-3-[4-(trifluoroMethyl)phenyl]propyl]- | [Molecular Formula]
C19H15F3O5 | [MDL Number]
MFCD28386242 | [MOL File]
1410101-89-1.mol | [Molecular Weight]
380.31 |
Chemical Properties | Back Directory | [Boiling point ]
577.9±50.0 °C(Predicted) | [density ]
1.400±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 230 mg/mL (604.77 mM; Need ultrasonic) | [form ]
Solid | [pka]
2.93±0.10(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of?PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment[1]. | [References]
[1] Wilhelm A, et al. 2-(3-Oxo-1,3-diphenylpropyl)malonic?acids?as?potent?allosteric?ligands?of the?PIF?pocket?of?phosphoinositide-dependent?kinase-1:?development?and?prodrug?concept.J Med Chem.?2012 Nov 26;55(22):9817-30. DOI:10.1021/jm3010477 |
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