| Identification | Back Directory | [Name]
UNC-1215 | [CAS]
1415800-43-9 | [Synonyms]
CS-714
UNC1215
UNC-1215
UNC 1215
UNC 1215, >=98%
UNC 1215; UNC1215
UNC-1215 USP/EP/BP
N-Phenyl-2,5-bis({[4-(pyrrolidin-1-yl)piperidin-1-yl]carbonyl})aniline
(2-(phenylaMino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)Methanone)
1,1'-[2-(Phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone]
Methanone, 1,1'-[2-(phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]-
UNC1215 1,1'-[2-(PhenylaMino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]Methanone]
[2-Phenylamino-4-(4-pyrrolidin-1-yl-piperidine-1-carbonyl)-phenyl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone
1,1'-[2-(Phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone] UNC 1215 | [Molecular Formula]
C32H43N5O2 | [MDL Number]
MFCD22683289 | [MOL File]
1415800-43-9.mol | [Molecular Weight]
529.716 |
| Chemical Properties | Back Directory | [Boiling point ]
712.1±60.0 °C(Predicted) | [density ]
1.224±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear | [form ]
powder | [pka]
9.90±0.20(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
UNC 1215 is ; a potent, selective antagonist of L3MBTL3 with cellular activity. UNC1215 binds the MBT domains of L3MBTL3 with a Kd of 120 nM, competitively displacing mono- or dimethyl-lysine containi
ng peptides | [Definition]
ChEBI: [3-anilino-4-[oxo-[4-(1-pyrrolidinyl)-1-piperidinyl]methyl]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is a member of benzamides and a N-acylpiperidine. | [Biological Activity]
UNC1215 is a potentselective antagonist of L3MBTL3 with cellular activity. Lethal (3) malignant brain tumor-like protein 3 (L3MBTL3) is a putative polycomb group (PcG) protein with gene-repressing activitya member of the MBT family of methyllysine binders. Methyl-lysine binding proteins are a family of proteins th at are important epigenetic regulators th at “read” the post-translational methylation state of histone lysine residues and modulate protein-protein interactions th at regulate gene expression. UNC1215 has an IC50 of 20 nM and > 100-fold selectivity over 13 HMTs and selected representatives of kinasesion channels7TMsand other epigenetic proteins. UNC1215 showed a significant decrease in FRAP recovery (Fluorescence Recovery After Photobleaching) time below 1 microM in cells using GFP-L3MBTL3. For full characterization detailsplease visit the UNC1215 probe summary on the Structural Ge | [target]
L3MBTL3 |
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