| Identification | Back Directory | [Name]
2-Piperidinemethanol, 1-[2-[4-[[4-(3,4-dichlorophenyl)-2-thiazolyl]amino]phenyl]ethyl]-4-hydroxy-, (2R,4S)- | [CAS]
1448706-15-7 | [Synonyms]
Amgen-23
2-Piperidinemethanol, 1-[2-[4-[[4-(3,4-dichlorophenyl)-2-thiazolyl]amino]phenyl]ethyl]-4-hydroxy-, (2R,4S)- | [Molecular Formula]
C23H25Cl2N3O2S | [MOL File]
1448706-15-7.mol | [Molecular Weight]
478.43 |
| Chemical Properties | Back Directory | [Boiling point ]
673.6±65.0 °C(Predicted) | [density ]
1.369±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.73±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Amgen-23 (compound 23) is a potent sphingosine kinases (SPHK) inhibitor with IC50 values of 20 nM and 1.6 μM for SPHK1 and SPHK2, respectively. Amgen-23 can be used for researching anticancer[1]. | [IC 50]
SphK1: 20 nM (IC50); SphK2: 1.6 μM (IC50) | [References]
[1] Gustin DJ, et al. Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4608-16. DOI:10.1016/j.bmcl.2013.06.030 |
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