| Identification | Back Directory | [Name]
(2S,3S)-N-[[2-Methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride | [CAS]
145877-52-7 | [Synonyms]
CP 122721 hydrochloride
(2S,3S)-N-[[2-Methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride | [Molecular Formula]
C20H25Cl2F3N2O2 | [MDL Number]
MFCD31656700 | [MOL File]
145877-52-7.mol | [Molecular Weight]
453.326 |
| Hazard Information | Back Directory | [Uses]
CP 122721 hydrochloride is a potent, non-peptide and selective nonpeptide neurokinin NK1 antagonist, with a pIC50 of 9.8 for human NK1 receptor expressed in IM-9 cells. CP 122721 hydrochloride exhibits anxiolytic and antidepressant-like effects[1][2]. | [IC 50]
human NK1: 9.8 (pIC50) | [storage]
Store at -20°C | [References]
[1] McLean S, et, al. Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor. J Pharmacol Exp Ther. 1996 May;277(2):900-8. PMID:8627572
[2] Kamel A, et, al. Metabolism and excretion of CP-122,721, a non-peptide antagonist of the neurokinin NK1 receptor, in dogs: identification of the novel cleaved product 5-trifluoromethoxy salicylic acid in plasma. Xenobiotica. 2007 May;37(5):559-78. DOI:10.1080/00498250701278434 |
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| Company Name: |
R&D Systems, Inc
|
| Tel: |
18003437475 18003437475 |
| Website: |
www.rndsystems.com |
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