| Identification | Back Directory | [Name]
Cyclophilin inhibitor 1 | [CAS]
1509904-96-4 | [Synonyms]
Cyclophilin inhibitor 1
Spiro[20H-7,2-([1]butenoxyethaniminoethano[1,3]-endo-pyridazinomethaniminomethano)quinoline-11,5'-[1,3]dioxane]-12,15,18,25-tetrone, 21,22,23,24-tetrahydro-17,27-dimethyl-14-(1-methylethyl)-, (9E,14S,17S,21S,27R)- | [Molecular Formula]
C31H39N5O7 | [MDL Number]
MFCD32062752 | [MOL File]
1509904-96-4.mol | [Molecular Weight]
593.68 |
| Hazard Information | Back Directory | [Uses]
Cyclophilin inhibitor 1 is a potent and orally bioavailable cyclophilin A inhibitor, with a Kd of 5 nM, shows effective anti-HCV activity, with an EC50 of 98 nM for HCV 2a[1]. | [IC 50]
Cyclophilin A | [References]
[1] Mackman RL, et al. Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle. J Med Chem. 2018 Nov 8;61(21):9473-9499. DOI:10.1021/acs.jmedchem.8b00802 |
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