| Identification | Back Directory | [Name]
Propargyl-PEG5-azide | [CAS]
1589522-62-2 | [Synonyms]
Propargyl-PEG5-N3
Propargyl-PEG5-azide
3,6,9,12,15-Pentaoxaoctadec-17-yne, 1-azido- | [Molecular Formula]
C13H23N3O5 | [MDL Number]
MFCD30458016 | [MOL File]
1589522-62-2.mol | [Molecular Weight]
301.34 |
| Hazard Information | Back Directory | [Uses]
Propargyl-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1012. DOI:10.1016/j.chembiol.2020.07.022 |
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