| Identification | Back Directory | [Name]
(S)-2-((S)-2-amino-3-methylbutanamido)-5-ureidopentanoic acid | [CAS]
159858-33-0 | [Synonyms]
Val-Cit
(S)-2-((S)-2-amino-3-methylbutanamido)-5-ureidopentanoic acid | [Molecular Formula]
C11H22N4O4 | [MDL Number]
MFCD32069532 | [MOL File]
159858-33-0.mol | [Molecular Weight]
274.32 |
| Chemical Properties | Back Directory | [Boiling point ]
554.0±50.0 °C(Predicted) | [density ]
1.218±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Solid | [pka]
3.13±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Val-Cit is a cleavable ADC linker used in antibody drug conjugate. The Val-Cit linker was designed to be cleaved by cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. | [Biological Activity]
Val-Cit is a cleavable ADC linker that can be used to synthesize antibody-drug conjugates (ADCs). | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
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