| Identification | Back Directory | [Name]
Cholic Acid Impurity 24 | [CAS]
16030-92-5 | [Synonyms]
Cholic Acid Impurity 24
3-beta,5-alfa,6-beta-Trihydroxycholanoic Acid | [Molecular Formula]
C24H40O5 | [MOL File]
16030-92-5.mol | [Molecular Weight]
408.57 |
| Chemical Properties | Back Directory | [Boiling point ]
560.2±40.0 °C(Predicted) | [density ]
1.203±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble; Methanol: soluble | [form ]
A solid | [pka]
4.76±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
3β,5α,6β-Trihydroxycholanic acid is a metabolite of 5α,6β-dihydroxycholestanol .1,2 It is increased in dried blood spots from patients with Niemann-Pick disease type C, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.2 | [References]
1. Kikuchi, S., Imai, Y., Suzuoki, Z., et al. Biologic studies of cholestane-3β,5α,6β-triol and its derivatives. III. The metabolic fate and metabolites of cholestane-3β,5α,6β-triol in animals J. Pharmacol. Exp. Ther. 159(2),399-408(1968).
2. Jiang, X., Sidhu, R.S., Mydock-McGrane, L., et al. Development of a bile acid-based newborn screen for Niemann-Pick disease type C Sci. Transl. Med. 8(337),337ra363(2016). |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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