| Identification | Back Directory | [Name]
PZII-029 | [CAS]
164025-44-9 | [Synonyms]
PZII-029
PZ-II-029
PZ-II-029 >=98% (HPLC)
7-Methoxy-2-(4-methoxyphenyl)-2H-pyrazolo[4,3-c]quinolin-3(5H)-one
2,5-Dihydro-7-methoxy-2-(4-methoxyphenyl)-3H-Pyrazolo[4,3-c]quinolin-3-one | [Molecular Formula]
C18H15N3O3 | [MDL Number]
MFCD26793884 | [MOL File]
164025-44-9.mol | [Molecular Weight]
321.33 |
| Chemical Properties | Back Directory | [Boiling point ]
475.8±55.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
7.22±0.20(Predicted) | [color ]
white to light brown |
| Hazard Information | Back Directory | [Uses]
PZ-II-029 is a GABAA positive allosteric modulator that selectively binds with high affinity to α6β3γ2. PZ-II-029 shows anti-migraine effects[1]. | [Biological Activity]
PZ-II-029 is the first compound to be identified as a specific postitive modulator of GABAA channels composed of α6β3γ2 subunits. | [in vivo]
PZ-II-029 (1-10 mg/kg; i.p.; 30 min before Capsaicin instillation) inhibits central and peripheral trigeminal responses in a rat migraine model[1]. | Animal Model: | Male Wistar rats (250-300 g; 8-10 weeks) induced by intra-cisternal (i.c.) instillation of Capsaicin[1]. | | Dosage: | 1, 3, or 10 mg/kg | | Administration: | i.p.; 30 min before Capsaicin instillation | | Result: | Significantly attenuated the trigeminal cervical complex (TCC) neuronal activation and trigeminal ganglia (TG) calcitonin gene-related peptide immunoreactivity (CGRP-ir) elevation, and dural CGRP depletion induced by capsaicin. |
| [storage]
Store at -20°C | [References]
[1] Pi-Chuan Fan, et al. The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. 2018 Sep 15:140:1-13. DOI:10.1016/j.neuropharm.2018.07.017 |
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| Company Name: |
BOC Sciences
|
| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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