| Identification | Back Directory | [Name]
Bepristat 1a | [CAS]
1642375-66-3 | [Synonyms]
Bepristat 1a
Bepristat 1a >=98% (HPLC)
4-Piperidinecarboxamide, 1-[(3-chloro-4-hydroxyphenyl)methyl]-N-ethyl-N-methyl-4-(2-phenoxyethyl)- | [Molecular Formula]
C24H31ClN2O3 | [MDL Number]
MFCD31697740 | [MOL File]
1642375-66-3.mol | [Molecular Weight]
430.97 |
| Chemical Properties | Back Directory | [Boiling point ]
563.1±50.0 °C(Predicted) | [density ]
1.190±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
8.42±0.20(Predicted) | [color ]
white to light brown |
| Hazard Information | Back Directory | [Biological Activity]
Beprist at 1a is a selective reversible inhibitor of protein disulfide isomerase (PDI)an enzyme in the endoplasmic reticulum th at catalyzes disulfide bond breakage and reformation to catalyze protein folding. Unlike most PDI inhibitorsBeprist at 1a binds at the substrate-binding siterather than the catalytic site. It blocked PDI activity with an IC50 value of 700 nM. PDI is up-regulated in several cancershas been implicated in neurodegenerative processesand plays an important role in thrombus formation. Beprist at 1a potently inhibited platelet aggregation and thrombus formation in vivo. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|