| Chemical Properties | Back Directory | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [Water Solubility ]
Soluble to 1 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
SAH-SOS1A is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM), directly and independently blocks nucleotide association, impairs KRAS-driven cancer cell viability, and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS[1]. | [in vivo]
SAH-SOS1A (0.2 μL of 10 mM solution; injection; 48 hours; abdomens of D. melanogaster Ras85DV12/ActinGS) treatment notably decreases the phosphorylation state of ERK1/2[1]. | [IC 50]
KRAS-SOS1; KRas G12C: 140 nM (EC50); KRas G12D: 109 nM (EC50); KRas G12V: 154 nM (EC50); KRas G12S: 155 nM (EC50); KRas Q61H: 175 nM (EC50); K-Ras WT: 106 nM (EC50) | [storage]
Store at -20°C | [References]
[1] Leshchiner ES, et al. Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices. Proc Natl Acad Sci U S A. 2015;112(6):1761-1766. DOI:10.1073/pnas.1413185112 |
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| Company Name: |
Struchem Co., Ltd.
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| Tel: |
0512-0512-63009836 15365350169 |
| Website: |
http://www.struchem.com |
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