| Identification | Back Directory | [Name]
1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT | [CAS]
168021-79-2 | [Synonyms]
CPI22
CPI-22
CPI 22
CXY059
OKN007
D03875
HPN-07
CS-791
OKN-007
CXY-059
CXY 059
OKN 007
ARL16556
Cerovive
ARL-16556
ARL 16556
Disufenton
NXY059/NXY-059
disufenton sodium
Cerovive(NXY-059)
NXY-059(Cerovive)
NXY-059(Disufentonsodium)
NXY 059 (CEROVIVE);NXY059
Disufenton sodium (NXY-059)
Disufenton sodium (usan/inn)
Disufenton sodiuM (NXY 059,Cerovive)
4-[[(1,1-Dimethylethyl)oxoimino]methyl]-1,3-benzenedisulfonicaciddisodiumsalt
Disodium,4-[(Z)-[tert-butyl(oxido)azaniumylidene]methyl]benzene-1,3-disulfonate
1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT
1,3-Benzenedisulfonic acid, 4-[[(1,1-dimethylethyl)imino]methyl]-, N-oxide, disodium salt
NXY059; NXY 059; NXY-059; CXY 059; CXY059; CXY-059; OKN007; OKN-007; OKN 007; ARL 16556; ARL16556; ARL-16556; CPI-22; CPI22; CPI 22; CEROVIVE; DISUFENTON SODIUM | [Molecular Formula]
C11H14NNa2O7S2 | [MDL Number]
MFCD09833648 | [MOL File]
168021-79-2.mol | [Molecular Weight]
382.341 |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 2mg/mL, clear |
| Hazard Information | Back Directory | [Uses]
A free radical trapping compound | [Uses]
Cerovive (NXY-059) is a novel nitrone, shows efficacious neuroprotective effects that prevents ischemic damage by trapping free radicals. Neuroprotectant. | [Biological Activity]
Free radical trapping agent. Reduces infarct size and preserves brain function in several animal models of acute ischemic stroke. Neuroprotectant. | [Biochem/physiol Actions]
Originally characterized for its NO-mimicking activity in preventing peroxynitrite formation and in vivo neuroprotective efficacy in animal models of cerebral ischemia (100 mg/kg i.v. in rabbits; 30-60 mg/kg plus 30-60 mg/kg/h i.v. or 50 mg/kg plus 8.8 mg/kg/h s.c. in rats; 28 mg/kg plus 16 mg/kg/h i.v. in monkeys), OKN-007 (HPN-07, NXY-059) is an orally available α-phenyl-tert-butylnitrone (PBN) derivative that is also shown to exhibit sulfatase 2 (SULF2) inhibitory activity and anticancer efficacy both in cultures (effective conc. 170-200 μM in Huh7 heptoma cultures) and in several rodent glioma models in vivo (C6, RG2, and GL261; 75 mg/kg/day for rats and 168 mg/kg/day for mice via drinking water). | [in vivo]
Disufenton sodium (28 mg/kg, iv and osmotic pump for 48 h) reduces cerebral infarction volume and improves behavioral dysfunction in marmoset permanent middle cerebral artery occlusion (pMCAO) models[2]. | Animal Model: | Marmoset pMCAO models[2] | | Dosage: | 60 mg/kg | | Administration: | 28 mg/kg for iv, 16 mg/kg?h for 48 h via osmotic pump | | Result: | Ameliorated ischemic brain injury. |
| [storage]
Store at -20°C | [References]
[1] kuroda s1, tsuchidate r, smith ml, maples kr, siesj? bk. |
|
| Company Name: |
T&W GROUP
|
| Tel: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.approvedhomemanagement.com/ShowSupplierProductsList15748/0_EN.htm |
|