| Identification | Back Directory | [Name]
Benzamide, 4-[[1-[[2-chloro-5-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]methoxy]-5-cyclopropyl-2-fluoro-N-(methylsulfonyl)- | [CAS]
1788071-27-1 | [Synonyms]
4-((1-(2-chloro-5-(trifluoromethyl)benzyl)piperidin-4-yl)methoxy)-5-cyclopropyl-2-fluoro-N-(methylsulfonyl)benzamide
4-[[1-[[2-Chloro-5-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]methoxy]-5-cyclopropyl-2-fluoro-N-(methylsulfonyl)-benzamide
Benzamide, 4-[[1-[[2-chloro-5-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]methoxy]-5-cyclopropyl-2-fluoro-N-(methylsulfonyl)- | [Molecular Formula]
C25H27ClF4N2O4S | [MOL File]
1788071-27-1.mol | [Molecular Weight]
563 |
| Chemical Properties | Back Directory | [density ]
1.392±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO|56.3|100| | [form ]
Solid | [pka]
3.41±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
4-[[1-[[2-Chloro-5-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]methoxy]-5-cyclopropyl-2-fluoro-N-(methylsulfonyl)-benzamide is a useful reagent in the preparation of substituted benzamides. | [in vivo]
GX-201 has a relatively long half-life in mice[1].
GX-201 produces analgesia at a free plasma concentration about 3 times the IC50[1].
GX-201 inhibits nociceptive responses induced by formalin and inflammatory pain caused by complete Freund’s adjuvant (CFA)[1].
| Animal Model: | Wild-Type Mice[1]. | | Dosage: | 0.3, 1, 3 mg/kg. | | Administration: | Orally, once. | | Result: | Produced a dose-dependent inhibition of the nociceptive events. |
| [IC 50]
Nav1.7: <3.2 nM (IC50) | [storage]
Store at -20°C |
|
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