| Identification | Back Directory | [Name]
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate | [CAS]
179688-53-0 | [Synonyms]
Gefitinib IMpurity VII
Gefitinib interMidiate IV
6-Acetoxy-7-methoxy-4-quinazolinol
6-Acetoxy-7-methoxyquinazolin-4(3H)-one
6-Acetoxy-7-Methoxy-4(3H)-quinazolinone
6-Acetoxy-7-methoxy-3H-quinazolin-4-one
6-ACETOXY-7-METHPXY-4-(3H)QUINAZOLINONE
6-Acetoxy-7-methoxy-4-hydroxyquinazoline
6-O-Acetyl-4-hydroxy-7-methoxy quinazoline
4-hydroxy-7-methoxyquinazolin-6-yl acetate
6-(Acetyloxy)-7-methoxy-4(3H)-quinazolinone
6-Acetoxy-7-methoxy-3H-quinazolin-4-one >
(7-methoxy-4-oxo-1H-quinazolin-6-yl) acetate
6-acetoxy-7-Methoxy-3,4-dihydroquizolin-4-one
6-Acetoxy-7-methoxy-3H-quinazolin-4-one
(4(3H)-Quinazolinone,6-(acetyloxy)-7-Methoxy- )
6-Acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one
3,4-Dihydro-4-oxo-6-acetoxy-7-methoxyquinazoline
4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
7-Methoxy-4-oxo-1,4-dihydroquinazolin-6-yl acetate
6-methoxy-4-oxo-3,4-dihydroquinazolin-7-yl acetate
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
7-Methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate
6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4(3H)-one
acetic acid (7-methoxy-4-oxo-1H-quinazolin-6-yl) ester
Acetic acid 7-methoxy-4-oxo-1,4-dihydro-quinazolin-6-yl ester | [EINECS(EC#)]
808-050-2 | [Molecular Formula]
C11H10N2O4 | [MDL Number]
MFCD09833010 | [MOL File]
179688-53-0.mol | [Molecular Weight]
234.21 |
| Chemical Properties | Back Directory | [Melting point ]
293 °C | [Boiling point ]
390.5±52.0 °C(Predicted) | [density ]
1.39 | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly) | [form ]
powder to crystal | [pka]
0.67±0.20(Predicted) | [color ]
White to Yellow | [InChI]
InChI=1S/C11H10N2O4/c1-6(14)17-10-3-7-8(4-9(10)16-2)12-5-13-11(7)15/h3-5H,1-2H3,(H,12,13,15) | [InChIKey]
SOLQIFINSOHAQD-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=C(OC(C)=O)C(OC)=C2)C(=O)NC=1 | [CAS DataBase Reference]
179688-53-0 |
| Hazard Information | Back Directory | [Chemical Properties]
Brown solid powder | [Uses]
4-Hydroxy-7-methoxyquinazolin-6-yl Ester Acetic Acid exhibit potent inhibitory activity against VEGFR-2/HDAC and a human breast cancer cell line MCF-7. | [Synthesis]
6-Hydroxy-7-methoxyquinazolin-4-one (1.92 g, 10 mmol) was placed in acetic anhydride (20 mL) and pyridine (4 mL) was added slowly with stirring. The reaction mixture was heated to 100 °C and kept for 4 hours. After the reaction was completed, it was cooled to room temperature and ice water was added to quench the reaction. The white solid that precipitated was the intermediate 7-methoxy-4-oxo-3,4-dihydroquinazolin-6-ol acetate (M-1, 2.32 g, 99% yield). | [References]
[1] Patent: CN106632089, 2017, A. Location in patent: Paragraph 0077; 0078; 0079
[2] Patent: CN106045980, 2016, A. Location in patent: Paragraph 0018; 0019; 0020
[3] Patent: EP1785420, 2007, A1. Location in patent: Page/Page column 18
[4] Patent: US2007/149523, 2007, A1. Location in patent: Page/Page column 13
[5] Patent: WO2005/97134, 2005, A2. Location in patent: Page/Page column 13; figure 1 |
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