| Identification | Back Directory | [Name]
S-acetyl-PEG4-t-butyl ester | [CAS]
1818294-26-6 | [Synonyms]
S-acetyl-PEG4-Boc
S-acetyl-dPEG5-t-boc
S-acetyl-PEG4-t-butyl ester
4,7,10,13-Tetraoxa-16-thiaoctadecanoic acid, 17-oxo-, 1,1-dimethylethyl ester | [Molecular Formula]
C17H32O7S | [MDL Number]
MFCD22574785 | [MOL File]
1818294-26-6.mol | [Molecular Weight]
380.5 |
| Hazard Information | Back Directory | [Description]
S-acetyl-PEG4-t-butyl ester is a PEG linker containing a sulfur acetyl group and a t-butyl ester. The sulfur acetyl group can be deprotected to form a thiol group. The t-butyl ester can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media. | [Uses]
S-acetyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|