| Identification | Back Directory | [Name]
Azido-PEG6-PFP ester | [CAS]
1818294-47-1 | [Synonyms]
Azido-PEG6-PFP ester
(2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate | [Molecular Formula]
C21H28F5N3O8 | [MDL Number]
MFCD26793784 | [MOL File]
1818294-47-1.mol | [Molecular Weight]
545.46 |
| Hazard Information | Back Directory | [Description]
Azido-PEG6-PFP ester is a a high purity PEG linker containing azide and PFP ester moities. The azide can participate in Click Chemistry reactions with alkynes, such as DBCO and BCN to form triazole groups. The PFP ester is amine-reactive and is less susceptible toward hydrolysis compared to NHS ester. | [Uses]
Azido-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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