Identification | Back Directory | [Name]
Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-β,β-dimethyl-, methyl ester | [CAS]
1822561-77-2 | [Synonyms]
methyl 2-((tert-butoxycarbonyl)amino)-3-methyl-3-phenylbutanoate Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-β,β-dimethyl-, methyl ester | [Molecular Formula]
C17H25NO4 | [MOL File]
1822561-77-2.mol | [Molecular Weight]
307.39 |
Hazard Information | Back Directory | [Uses]
Taltobulin intermediate-11 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1]. | [References]
[1] Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45. PMID:12702571 |
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