天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->183322-16-9

183322-16-9

183322-16-9 Structure

183322-16-9 Structure
IdentificationBack Directory
[Name]

Ethyl 3,4-bis(2-methoxyethoxy)benzoate
[CAS]

183322-16-9
[Synonyms]

183322-16-9
ERLOTINIBINT-B
Erlotinib interMediate II
Ethyl 3,4-bis(2-methoxyethoxy)
3,4-bis(2-methoxyethoxy)benzoate
Erlotinib Hydrochloride iMpurity 30
Thyl3,4-bis(2-methoxyethoxy)benzoate
Ethyl 3,4-bis(2-methoxyethoxy)benzoate
3,4-Bis(2-methoxyethoxy)benzoic acid ethyl ester
3,-bis(2-methoxyethoxy)-benzoic acid ethyl ester
Benzoic acid,3,4-bis(2-Methoxyethoxy)-, ethyl ester
[EINECS(EC#)]

605-991-9
[Molecular Formula]

C15H22O6
[MDL Number]

MFCD01935284
[MOL File]

183322-16-9.mol
[Molecular Weight]

298.33
Chemical PropertiesBack Directory
[Melting point ]

55-58 °C
[Boiling point ]

401.7±45.0 °C(Predicted)
[density ]

1.102
[storage temp. ]

Sealed in dry,Room Temperature
[form ]

powder to crystal
[color ]

White to Almost white
[InChI]

InChI=1S/C15H22O6/c1-4-19-15(16)12-5-6-13(20-9-7-17-2)14(11-12)21-10-8-18-3/h5-6,11H,4,7-10H2,1-3H3
[InChIKey]

VGFZRAVMWXHEJB-UHFFFAOYSA-N
[SMILES]

C(OCC)(=O)C1=CC=C(OCCOC)C(OCCOC)=C1
Safety DataBack Directory
[HS Code ]

2916.31.5000
Hazard InformationBack Directory
[Uses]

3,4-bis(2-Methoxyethoxy)benzoic Acid Ethyl Ester is a compound used in the synthesis of Erlotinib (E625008), a cancer treatment medicine.
[Synthesis]

Ethyl 3,4-dihydroxybenzoate

3943-89-3

1-Bromo-2-methoxyethane

6482-24-2

Ethyl 3,4-bis(2-methoxyethoxy)benzoate

183322-16-9

(3) Preparation of ethyl 3,4-bis(2-methoxyethoxy)benzoate 13: Ethyl 3,4-dihydroxybenzoate 12 (5 g, 27.45 mmol) was placed in a 250 mL two-necked flask and acetone (100 mL), potassium carbonate (9.48 g, 68.63 mmol), potassium iodide (0.5 g) and 2-bromoethyl methyl ether ( 7.84 mL, 82.35 mmol). The reaction mixture was heated to reflux at 60 °C for 19 hours. Upon completion of the reaction, the reaction solution was cooled to 5 °C and stirred for 30 min, followed by filtration and concentration to dryness. The resulting solid was dried by oil pumping for 22 h to give the khaki colored solid product 13 (8.19 g, 100% yield).1H-NMR (CDCl3) data: δ 1.32 (t, 3H, J = 7Hz), 3.41 (s, 6H), 3.76 (m, 4H), 4.15 (m, 4H), 4.29 (q, 2H, J = 7Hz), 6.85 (d, 1H, J = 8.4Hz), 7.53 (dd, 1H, J = 8.4Hz, J = 2.3Hz), 7.63 (dd, 1H, J = 8.4Hz, J = 2.3Hz).

[References]

[1] Patent: US2010/267949, 2010, A1. Location in patent: Page/Page column 6
[2] Patent: EP1614676, 2006, A1. Location in patent: Page/Page column 194
[3] Patent: EP2163546, 2016, B1. Location in patent: Paragraph 0125
[4] European Journal of Medicinal Chemistry, 2008, vol. 43, # 7, p. 1478 - 1488
[5] Chemistry - A European Journal, 2015, vol. 21, # 41, p. 14342 - 14346
Spectrum DetailBack Directory
[Spectrum Detail]

Ethyl 3,4-bis(2-methoxyethoxy)benzoate(183322-16-9)1HNMR
183322-16-9 suppliers list
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: Jinan Shengqi pharmaceutical Co,Ltd
Tel: 86+18663751872
Website: www.shengqipharm.com
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Website: www.hubeijusheng.com
Company Name: Jinan Finer Chemical Co., Ltd
Tel: +86-531-88989536 +86-15508631887 , +86-15508631887
Website: www.finerchem.com
Company Name: Standardpharm Co. Ltd.
Tel: 86-714-3992388
Website: www.standardpharm.com
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Website: www.approvedhomemanagement.com/ShowSupplierProductsList454175/0_EN.htm
Company Name: Shanghai Yingrui Biopharma Co.,Ltd
Tel: 21-33585366
Website: www.shyrchem.com
Company Name: SIMAGCHEM CORP
Tel: +86-5922680277 +86-13806087780 , +86-13806087780
Website: http://www.simagchem.com/
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226 , 13588875226
Website: www.hzclap.com/en
Company Name: AFINE CHEMICALS LIMITED
Tel: +86-0571-85134551
Website: www.afinechem.com/index.html
Company Name: Dayang Chem (Hangzhou) Co.,Ltd.
Tel: +86-0571-88938639 +8617705817739 , +8617705817739
Website: www.dycnchem.com/
Company Name: CR Corporation Limited
Tel: +8613062833949 , +8613062833949
Website: http://www.crcorporation.cn/
Company Name: Wisdom Drugs Co .,Ltd
Tel: +86-0519-85556805
Website: https://www.wisdomdrugs.com/
Company Name: sgtlifesciences pvt ltd
Tel: +8617013299288 , +8617013299288
Website: http://www.approvedhomemanagement.com/ShowSupplierProductsList1846349/0.htm
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: +86-0551-65418684 +8618949823763 , +8618949823763
Website: www.tnjchem.com
Company Name: Hebei Fengjia New Material Co., Ltd
Tel: +86-0311-87836622 +86-18712993135 , +86-18712993135
Website: www.approvedhomemanagement.com/ShowSupplierProductsList1283525/0_EN.htm
Company Name: PT CHEM GROUP LIMITED
Tel: +86-85511178;
Website: http://www.approvedhomemanagement.com/manufacturer/henan-lihao-chem-plant-25020/
Company Name: Hu Bei Jiutian Bio-medical Technology CO.,Ltd
Tel: 027-88013699 17354350817 , 17354350817
Website: www.jiutian-bio.com
Tags:183322-16-9 Related Product Information
456-55-3 140-88-5 532-32-1 141-78-6 96-33-3 10497-05-9 64-17-5 90-05-1 150-76-5 462-95-3 120-51-4 91-53-2 93-89-0 100-66-3 120-47-8 3734-33-6 3943-89-3 179688-26-7

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.