| Identification | Back Directory | [Name]
N-Me-N-(PEG2-propargyl)2 | [CAS]
1835759-84-6 | [Synonyms]
N-Me-N-(PEG2-propargyl)2
N-methyl-2-(2-prop-2-ynoxyethoxy)-N-[2-(2-prop-2-ynoxyethoxy)ethyl]ethanamine
Ethanamine, N-methyl-2-[2-(2-propyn-1-yloxy)ethoxy]-N-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]- | [Molecular Formula]
C15H25NO4 | [MDL Number]
MFCD29042338 | [MOL File]
1835759-84-6.mol | [Molecular Weight]
283.36 |
| Chemical Properties | Back Directory | [Boiling point ]
353.6±37.0 °C(Predicted) | [density ]
1.025±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
7.83±0.50(Predicted) |
| Hazard Information | Back Directory | [Description]
N-Me-N-bis(PEG2-propargyl) has two alkyne groups which can participate in Click Chemistry reactions with azide-bearing compounds or biomolecules; copper is required for catalyzation. | [Uses]
N-Me-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Me-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|