| Identification | Back Directory | [Name]
Carbamic acid, (3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester (9CI) | [CAS]
184357-44-6 | [Synonyms]
3-(Boc-amino)-2,2-dimethylpropanol
3-(Boc-aMino)-2,2-diMethyl-1-propanol
tert-Butyl (3-hydroxy-2,2-dimethylpropyl)
Tert-butyl 3-Hydroxy-2,2-dimethylpropylcarbamate
Carbamic acid, (3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester (9CI) | [Molecular Formula]
C10H21NO3 | [MDL Number]
MFCD09951814 | [MOL File]
184357-44-6.mol | [Molecular Weight]
203.28 |
| Chemical Properties | Back Directory | [Boiling point ]
311.0±25.0 °C(Predicted) | [density ]
0.998±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
12.67±0.46(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
Step 1: Synthesis of tert-butyl (3-hydroxy-2,2-dimethylpropyl) carbamate: 3-amino-2,2-dimethyl-1-propanol (1.50 g, 14.5 mmol) was dissolved in dichloromethane (70 ml) followed by addition of di-tert-butyl dicarbonate (3.49 g, 16.0 mmol). The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, saturated ammonium chloride solution (NH4Cl) was added and stirring was continued for 10 minutes. The organic and aqueous layers were separated, and the organic phase was washed with saturated sodium bicarbonate solution (NaHCO3), dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford the target product, 2,2-dimethyl-3-(Boc-amino)-1-propanol, as a white solid (3.40 g, quantitative yield).The LC-MS analysis showed the molecular ion peak as 226.20 (M + Na+). | [References]
[1] Patent: WO2011/71725, 2011, A1. Location in patent: Page/Page column 53
[2] ChemMedChem, 2014, vol. 9, # 1, p. 197 - 206
[3] Patent: WO2006/57868, 2006, A1. Location in patent: Page/Page column 72
[4] Patent: WO2018/109648, 2018, A1. Location in patent: Page/Page column 52; 56
[5] Patent: US2005/54701, 2005, A1 |
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