| Identification | Back Directory | [Name]
Ginsenoside-Rg5 | [CAS]
186763-78-0 | [Synonyms]
Ginsenoside-Rg5
Ginsenoside Rg5, >99%
Ginsenoside Rg5, 98%, from Panax ginseng C. A. Mey.
b-D-Glucopyranoside, (3b,12b,20E)-12-hydroxydammara-20(22),24-dien-3-yl 2-O-b-D-glucopyranosyl-
β-D-Glucopyranoside, (3β,12β,20E)-12-hydroxydammara-20(22),24-dien-3-yl 2-O-β-D-glucopyranosyl-
(3beta,12beta,20E)-12-Hydroxydammara-20(22),24-dien-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
(8ξ,9ξ,12α,13ξ,14β,17β)-12-Hydroxy-4,4,7,10,14-pentamethyl-17-[(2 E)-6-methyl-2,5-heptadien-2-yl]gonan-3-yl 2-O-β-D-glucopyranosyl- β-D-glucopyranoside | [Molecular Formula]
C42H70O12 | [MDL Number]
MFCD22200429 | [MOL File]
186763-78-0.mol | [Molecular Weight]
767 |
| Chemical Properties | Back Directory | [Boiling point ]
855.6±65.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO; sparingly soluble in methanol; | [form ]
powder | [pka]
12.85±0.70(Predicted) | [color ]
White | [Water Solubility ]
insoluble in water | [InChIKey]
NJUXRKMKOFXMRX-SELNEYDKSA-N |
| Hazard Information | Back Directory | [Uses]
Ginsenoside Rg5 is an aromatase inhibitor from Panax ginseng leaves. Also, it ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of inflammation, oxidative stress, and apoptosis. | [Definition]
ChEBI: A natural product found in Panax japonicus var. major. | [in vivo]
Ginsenoside Rg5 inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65 in lipopolysaccharides (LPS)-stimulated BV2 microglial cells. Rg5 pretreated group mice show declined expression of NF-κB p65 and COX-2. In the group treated with low dose of Ginsenoside Rg5 (10 mg/kg), there is remarkable tubular damage and infiltration of inflammatory cells. However, at the higher dose of Ginsenoside Rg5 (20 mg/kg), tubules markedly appeare histologically normal and no inflammation and cast formation is observed in kidney tissues[2]. | [target]
TNF-α | IL Receptor | AChR | COX | NOS | Beta Amyloid | ERK | FAK | Akt | MMP(e.g.TIMP) | NF-kB | AP-1 | ROS | HO-1 | TLR | CDK | p21 | [IC 50]
IGF-1R: 90 nM (IC50); p65; COX-2 | [storage]
Store at -20°C |
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