| Hazard Information | Back Directory | [Uses]
RS 102221 Hydrochloride is a selective 5-HT2C receptor antagonist. | [in vivo]
RS-102221 hydrochloride (2 mg/kg; i.p.; once daily for 14 d) increases food-intake and weight-gain in rats[2].
RS-102221 hydrochloride (2 mg/kg; i.p.; single dose), combined with the 3,4-Methylenedioxy-N-methamphetamine (MDMA or 'ecstasy'), suppresses the MDMA-induced hypophagia for the first 1 h period, and also suppresses MDMA-induced hyperlocomotion in mice[3].
RS-102221 hydrochloride (2 mg/kg; i.p.; single dose) can reduce anxiety and reduce the amplitude of startle reflex in mice in light and dark test[4].
| [IC 50]
5-HT2C Receptor: 10 nM (Ki); 5-HT2A Receptor; 5-HT2B Receptor | [storage]
Store at RT |
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